Peptide and Peptidomimetic Therapeutics

Peptide and Peptidomimetic Therapeutics

From Bench to Bedside

Rubin, Samuel J.S.; Qvit, Nir

Elsevier Science Publishing Co Inc

09/2022

792

Mole

Inglês

9780128201411

15 a 20 dias

1250

Descrição não disponível.
History 1. Therapeutic peptides: historical perspectives and current development trends

Basic science 2. Therapeutic peptidomimetics: targeting the undruggable space 3. Tailoring peptides and peptidomimetics for targeting protein-protein interactions 4. Advances in peptide synthesis 5. Stapled peptidomimetic therapeutics 6. Ring closing metathesis

Drug discovery 7. The current state of backbone cyclic peptidomimetics and their application to drug discovery 8. Pharmacokinetics and pharmacodynamics of peptidomimetics 9. Formulations of peptides and peptidomimetics 10. Cell-penetrating peptides 11. Intracellular peptides as drug prototypes 12. Applications of computational three-dimensional structure prediction for antimicrobial peptides

Therapeutic applications 13. Knottin peptidomimetics as therapeutics 14. Venom peptidomimetics as therapeutics 15. Therapeutic peptides targeting protein kinase: progress, challenges and future directions, featuring cancer and cardiovascular disease 16. Therapeutic peptidomimetics for infectious diseases 17. Antiparasitic therapeutic peptidomimetics 18. Peptides and antibiotic resistance 19. Antimicrobial peptides and the skin and gut microbiomes 20. Peptide and peptidomimetic based vaccines 21. Therapeutic peptidomimetics for cancer treatment 22. Immunomodulatory peptidomimetics for multiple sclerosis therapy - the story of glatiramer acetate (Copaxone) 23. Therapeutic peptidomimetics in metabolic diseases 24. Therapeutic peptidomimetics in anesthesiology 25. Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease 26. Non-cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease

Drug development 27. Clinical and preclinical data on therapeutic peptides 28. Therapeutic peptides: manufacturing and market 29. Future perspectives on peptide therapeutics
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ADME; Ab initio modeling; Adrenomedullin; Amino acid analogs; Aminocaproic acid; Aminopeptidases; Amylin; Anesthesiology; Angiotensin II; Antibiotic resistance; Antibody mimetic; Antimicrobial peptides; Antimicrobial resistance; Antiparasitic drugs; Apelin; Apoptosis regulation; Atrial natriuretic peptide; Autoimmunity; AzabicycloXY0alkanone amino acid; B-type natriuretic peptide; Backbone cyclization; Bioavailability; Bivalirudin; Bradykinin; C-type natriuretic peptide; Calcitonin gene-related protein; Cancer; Cancer therapy; Cardiovascular disease; Cardiovascular diseases; Cardiovascular system; Carperitide; Cell-penetrating peptides; Cenderitide; Chemical alteration; Circulatory system; Clearance; Clinical development; Clinical trials; Comparative modeling; Constrained peptides; Contact map; Copaxone; Copolymer; Cyclic heptapseudopeptides; Cyclization; Cyclosporine; Cysteine bridges; D-peptide; DPP-4; Dendroaspsis natriuretic peptide; Desirudin; Desmopressin; Diabetes; Diagnostics; Double staple; Drug delivery; Drug design; Drug development; Drug discovery; Drugs; Ecallantide; Endocytosis; Endothelin; ss-turn; Epitopes; Eptifibatide; Experimental autoimmune encephalomyelitis (EAE); Extended structures; Fluorenylmethyloxycarbonyl (Fmoc); Formulation; GIP; GLP-1; GLP-2; Ghrelin; Glatiramer acetate; Glicentin; Glucagon; Half-life; Helix mimetics; Hormone receptors; Immune stimulants; Immunomodulation; Incretin; Infectious diseases; Inflammation; Inpeps; Insulin; Integrins; Intracellular peptides; Kinase inhibitor; Kinetoplastida; Knottin; Lebetin; MD simulations; Malaria; Medicinal chemistry; Metalloproteinases; Microbiome; Multidrug-resistance