Principles of Cloning

1. Cloning History and Universal Principles

Part I Basics
2. Multiplying Embryos: Experimental Monozygotic Polyembryony in Mammals and its uses
3. Artificial Activation of Mammalian Oocytes
4. Nuclear Origins and Clone Phenotype
5. Genetic and Phenotypic Similarity Among Members of Mammalian Clonal Sets

Part II Methods
6. Micromanipulation Techniques for Cloning
7. Handmade Cloning
8. Culture of Viable Mammalian Embryos In Vitro
9. Pregnancy and Neonatal Care of SCNT Animals
10. Donor Cell Type and Cloning Efficiency in Mammals
11. Enhancing SCNT with Chromatin Remodeling Agents
12. Cell Cycle Regulation in Cloning

Part III Cloning by Species
13. Amphibia
14. Medaka Fish
15. Zebrafish
16. Goldfish
17. Mice
18. Rabbits
19. Pigs
20. Cows
21. Dogs
22. Equids
23. Macaque Monkeys

Part IV Complementary Technologies
24. Genome Editing in Somatic Cells
25. Targeted Chromosome Elimination from ES-Somatic Hybrid Cells

Part V Applications
26. Nuclear Transfer for Stem Cells
27. Embryonic Stem Cell in Bovine (other species?)
28. Commercial Applications of Cloning Technology
29. Production of Recombinant Therapeutic Proteins
30. Generation of Transgenic Domestic Species via Somatic Cell Nuclear Transfer
31. Commercializing Genetically Engineered Cloned Cattle
32. Cloning Endangered Species
33. Genetically Engineered Pigs for Medicine

Part VI Mechanisms
34. Histone Methylation During Somatic Cell Nuclear Transfer
35. Nuclear Transfer with Germ Cells: Germ Cell Cloning Contributes to current Understanding of Genomic Imprinting in Mammals
36. Clone-Specific X-Linked Gene Repression Caused by Ectopic Xist Transcripts from the Active X Chromosome
37. Cell Division and Nuclear Reprogramming
38. Reprogramming Machinery of the Mouse Oocyte - Proteomic Analyses
39. Biological Age of Cloned Animals
40. Mitochondrial Inheritance in Cloned Animals
41. Interspecies Somatic Cell Nuclear Transfer
42. Epigenetics of Cloned Livestock Embryos and Offspring
43. Role of iPSC-Producing Factors in Pre-Implantation Embryos
44. Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos
45. Genome Exchange in Human Oocytes

Part VII Ethical, Regulatory and Legal Affairs
46. Ethical Implications of Reproductive Cloning
47. An Overview of the Regulatory Considerations for Animal Cloning in the USA
48. Regulation and safety considerations of somatic cell nuclear transfer-cloned farm animals and their offspring used for food production - the European Union perspective
49. Asian Regulatory Landscape on Animal Cloning
50. South American Governmental guidelines for the production and commercialization of Cloned Animals

Part VIII Cloning Outlook
51. Somatic cell nuclear transfer: failures, successes, and the challenges ahead

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• Engenharia genética
• Genética (não médica)

Cloning; Oocytes; SCNT; Genome Editing; Somatic Cells; Stem Cells; Epigenetics; Embryos