Hereditary Gastric and Breast Cancer Syndrome

Part I. Epidemiology.- Family History and the Risk of Breast and Gastric Cancer.- Worldwide CDH1 Germline Mutation Frequency and the Transhormesis Hypothesis.- Hereditary Lobular Breast Cancer: A Newly Defined Syndrome.- Part II. Genetics.- Genetic Counseling and Prevention in Families at High Risk for HDGC and Other Hereditary Syndromes.- CTNNA1, a New HDGC Gene: Inactivating Mechanisms and Driven Phenotypes.- Revisiting the Biological and Clinical Impact of CDH1 Missense Variants.- Other Syndromes and Genes Associated with Gastric Cancer Predisposition.- Computer-Assisted Interpretation of Cancer-Predisposing Variants.- Part III. Pathology.- Histopathology of Hereditary Diffuse Gastric Cancer: From Grossing and 3D Microscopy to Immunophenotypic and Molecular Profiling.- HER2 Testing in Breast and Gastric Cancer with CDH1 Germline Mutations.- Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers.- Part IV. Endoscopy and Imaging.- Endoscopy:Is there Anything New?.- Endoscopic Surveillance and Pathology of Biopsies in CDH1, CTNNA1 and HDGC-Like Families.- Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon.- Part V. Surgery.- Prophylactic Total Gastrectomy: Techniques.- Prophylactic Total Gastrectomy: How Many?.- Hereditary Lobular Breast Cancer Syndrome: Role of Surgery.- Breast Reconstruction.- Part VI. New Issues.- Psychological Burden and Preferences in CDH1 Mutation Carriers: Beyond the Cancer Diagnosis.- Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives.- The Chemoprevention of Hereditary Diffuse Gastric Cancer.- Malformations and Malformative Syndromes Associated with CDH1.- Hereditary Breast Cancer Non-CDH1 Associated.- Part VII. Patient Advocacy.- My Hereditary Gastric Cancer.- Hereditary Breast Cancer Syndrome, My Experience.- Part VIII. Miscellaneous.- ?-Hemoglobinopathies and Early Onset of Cancers in Adulthood. Epidemiology in Southeastern Asia & Brunei with Emphasis for Prevention and Treatment.

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• Oncologia
• Genética (não médica)

Breast Cancer;Brest Imaging;CDH1 Gene;Endoscopy;E-Cadherin;Gastric Cancer;Gene Mutation;Genetic Testing;Hereditary Diffuse Gastric Cancer;Hereditary Lobular Breast Cancer;Prophylactic Bilateral Mastectomy;Prophylactic Total Gastrectomy