Handbook for Chemical Process Research and Development, Second Edition

1. Reaction solvent selection

2. Reagent selection

3. Various reagent surrogates

4. Modes of reagent addition -control of impurity formation

5. Process optimization with additives

6. Process optimization of catalytic reactions

7. Process optimization of problematic reactions

8. Hazards of oxidation and reduction reactions

9. Other hazardous reactions

10. Hazardous reagents

11. Grignard reagent and related reactions

12. Challenging reaction intermediates

13. Protecting groups

14. Telescope approach

15. Design of new synthetic route

16. Stereochemistry

17. Various quenching strategies

18. Various isolation and purification strategies

19. Methods for residual metal removal

20. Methods for impurity removal

21. Pharmaceutical salts

22. Solid form

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Synthetic organic chemistry;Process chemistry;Scaling up;Mechanism-guided process development;Chemical processes;Process research and development;Stereochemistry and asymmetric;Grignard Reagents;Postreaction Mixture;Reaction Mixture;Phosphorus Oxychloride;Process Res;Bisulfite Adduct;Amide Formation;Sodium Tungstate Dihydrate;Aryl Bromides;Cross-coupling Reaction;Aqueous NaOH;Suzuki Cross-coupling Reaction;Weinreb Amide;Fisher Indole Synthesis;Diisobutyl Aluminum Hydride;Grignard Reaction;Functional Group Protection;HCl Salt;Propylene Glycol Monomethyl Ether;PGME;Sonogashira Reaction;Suzuki Coupling Reaction;Telescoped Process;Diastereomeric Salt;Hot Melt Extrusion