Handbook of Medicinal Chemistry

Physicochemical Properties;

Synthesis in Medicinal Chemistry;

Useful Computational Chemistry Tools for Medicinal Chemistry;

Structure-based Design for Medicinal Chemists;

Fragment-based Ligand Discovery;

Machine Learning in Drug Design;

Drug Metabolism;

ADME Optimization in Drug Discovery;

Molecular Biology for Medicinal Chemists;

Assays;

In Vitro Biology: Measuring Pharmacological Activity That Will Translate to Clinical Efficacy;

Animal Models: Practical Use and Considerations;

Bioinformatics for Medicinal Chemistry;

Translational Science;

Discovery Toxicology in Lead Optimization;

Toxicology and Drug Development;

Patents for Medicines;

Target Validation for Medicinal Chemists;

Lead Optimisation: What you should know!;

Pharmaceutical Properties - The Importance of Solid Form Selection;

The Medicinal Chemistry and Process Chemistry Interface;

Clinical Drug Development;

SMN2 Splicing Modification by Small Molecules - A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases;

The Discovery of Checkpoint Kinase 1 Inhibitors: From Fragments to Clinical Candidate;

Medicinal Chemistry for Neglected Diseases - Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis and River Blindness;

New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug Discovery

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• Bioquímica
• Tecnologia farmacêutica
• Química orgânica

synthetic route development; predictive toxicology; lead generation strategies; pharmacokinetics; QSAR models; drug optimization; drug metabolism; drug design