Epigenetic Drug Discovery

Introduction to Drug Discovery in Epigenetics
Assay Development and Screening Strategies for Epigenetic Targets
Mass Spectrometry and Chemical Biology Approaches for Deconvoluting Epigenetic Targets
Recent Developments in the Structural Mechanism of Protein Methyltransferase Inhibition
Epigenomic Sequencing Technologies
Safety Consideration of Targeting Epigenetic Mechanisms
Toward Understanding Pharmacological Modulation of DNA Methylation and Its Effects on Gene Expression
Histone Deacetylases
Chemical Targeting of Histone Acetyltransferases
Histone Lysine Methyltransferases
Inhibiting Arginine Methylation
Histone Demethylases
Targeting the Human Acetylation Reader Family: Bromodomain Proteins
Targeting Histone Readers: Non-bromodomain Readers
Arising Opportunities and Challenges of Targeting Chromatin Remodelers
RNA Modifying Proteins: Emerging Targets for Drug Discovery
Directly Targeting RNA with Drug-like Small Molecules
Discovery and Development of Tazemetostat
Menin Inhibitors: Discovery, Development and Clinical Translation
Discovery of MTA-cooperative PRMT5 Inhibitors

Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.

• Bioquímica
• Genética (não médica)
• Biologia Celular (citologia)
• Química
• Medicina pré-clínica: ciências básicas
• Farmacologia

toxicology; DNA; molecular biology; RNA