Nuclear Receptors in Human Health and Disease
portes grátis
Nuclear Receptors in Human Health and Disease
Bevan, Charlotte L.; Campbell, Moray J.
Springer International Publishing AG
09/2022
346
Dura
Inglês
9783031118357
15 a 20 dias
975
Descrição não disponível.
Introduction (Moray J Campbell & Charlotte L Bevan).- Overview (Jason Carroll).- Part I: Reproduction and Development.- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson).- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders).- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh).- Part II: Metabolism.- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm).- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni).- Part III: Central Systems.- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman).- Chapter 7. Physiological convergence and antagonism between GR and PPAR? in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky).- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray).- Chapter 9. Vitamin D and gut health (James C Fleet).- Part IV: Cancer.- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn).- Chapter 11. AR structural variants and prostate cancer (Laura Cato).- Chapter 12. ER? and inflammation (Linnea Hases, Amena Archer & Cecilia Williams).- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell).- Part V: New developments in transcriptional control by nuclear receptors.- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil).- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart).- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan).- Part VI: Clinical Translation.- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe).- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar).- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki).- Index.
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Cancer;Development;Drug design;Epigenomics;Genomics;Metabolism;Reproduction
Introduction (Moray J Campbell & Charlotte L Bevan).- Overview (Jason Carroll).- Part I: Reproduction and Development.- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson).- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders).- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh).- Part II: Metabolism.- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm).- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni).- Part III: Central Systems.- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman).- Chapter 7. Physiological convergence and antagonism between GR and PPAR? in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky).- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray).- Chapter 9. Vitamin D and gut health (James C Fleet).- Part IV: Cancer.- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn).- Chapter 11. AR structural variants and prostate cancer (Laura Cato).- Chapter 12. ER? and inflammation (Linnea Hases, Amena Archer & Cecilia Williams).- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell).- Part V: New developments in transcriptional control by nuclear receptors.- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil).- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart).- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan).- Part VI: Clinical Translation.- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe).- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar).- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki).- Index.
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