Antibody Glycosylation

Microheterogeneity of antibody molecules.- Part I: Analytical Methods.- Lectin and LC based methods for immunoglobulin (G) glycosylation analysis.- Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis.- CE based methods for Ig(G) glycosylation analysis.- Automation of Ig glycosylation analysis.- Bioinformatics in immunoglobulin glycosylation analysis.- Part II: Biosynthesis & Regulation.- N-glycan biosynthesis: Basic principles and factors affecting its outcome.- Genetic regulation of immunoglobulin G glycosylation.- Epigenetics of immunoglobulin G glycosylation.- IgG changes in aging and other inflammatory conditions.- Estrogen-driven changes in immunoglobulin G Fc glycosylation.- Part III: Effector Functions & Diseases.- Sweet rules - linking glycosylation to antibody function.- Immunoglobulin G glycosylation in diseases.- Immunoglobulin A glycosylation and its role in diseases.- Part IV: Applications.- Importance and monitoring of therapeutic immunoglobulin G glycosylation.- Glycosylation of plant-produced immunoglobulins.- The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine.- Glycosylation of antigen-specific antibodies - Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.

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• Biotecnologia
• Pesquisa médica
• Imunologia
• Farmacologia
• Química analítica

Immunoglobulin;Ig(G) glycosylation;Posttranslational modifications;Glycoanalytics;Biomarker;Immunotherapy;Vaccination;Glycoscience