Human Challenge Studies for Vaccine Development

Human Challenge Studies for Vaccine Development

Bagnoli, Fabio; Del Giudice, Giuseppe; Rappuoli, Rino; Phogat, Sanjay K.

Springer International Publishing AG

10/2024

377

Dura

9783031631177

15 a 20 dias

Descrição não disponível.
A brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d'etre, ethnography, selection of volunteers and unit design.- Regulatory aspects of human challenge studies.-Controlled Human Infection challenge studies with RSV.- Human challenge studies with coronaviruses old and new.- Experimental urethral infection with Neisseria gonorrhoeae.- Helicobacter pylori.-Controlled human infection with Bordetella pertussis

Human challenge studies for cholera.- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli.- Challenges in developing a controlled human tuberculosis challenge model.- Shigella Controlled Human Infection Models: Current and Future Perspectives.- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella.- Controlled Human Malaria Infection studies in Africa - past, present, and future.- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development.
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Human Challenge trials;Controlled Human Infection Studies;monoclonal antibody;Re-emerging Virus;SARS;Dengue;Cholera;Malaria;clinical trial regulation;clinical trial ethics