Drug Stereochemistry
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Drug Stereochemistry
Analytical Methods and Pharmacology, Third Edition
Jozwiak, Krzysztof; Wainer, Irving W.; Lough, W. J.
Taylor & Francis Ltd
10/2024
330
Mole
9781032921884
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Introduction: The Early History of Stereochemistry: From the Discovery of Molecular Asymmetry and the First Resolution of a Racemate by Pasteur to the Asymmetrical Chiral Carbon of Van't Hoff and Le Bel. Stereochemical Terms and Concepts: An Overview. Molecular Chiral Recognition: An Introduction and Overview. The Role of Stereo-Chemistry in the Development of ACE Inhibitors: Nature to Clinic. The Separation, Preparation and Identification of Stereochemically Pure Drugs: Indirect Methods for the Chromatographic Resolution of Drug Enantiomers: Synthesis and Separation of Diastereo-Metric Derivatives. The Direct Resolution of Enantiometric Drugs by Chiral Phase Gas Chromatography. HPLC Chiral Stationary Phases for the Stereochemical Resolution of Enantiometric Compounds: The Current State of the Art. Enantioselective Separations by Capillary Electrophoresis. Recent Advances in the Synthesis of Enantiomerically Pure Compounds. Production Scale Preparation of Enantiomerically Pure Compounds by Chromatography and Synthetic Approaches. Spectrometric Identification and Characterization of Chiral Molecules. Pharmacokinetic and Pharmacodynamic Differences Between Drug Stereoisomers: Stereochemical Considerations in the ADMET Stage of Drug Development. Stereoselective Biotransformations: Toxico-Logical Consequences and Implications. Stereoselective Interactions with Enzymes and Their Use in Drug Development. Stereoselective Transport of Drugs Across Epithelia. Clinical Pharmacokinetics and pharmacodynamics of Stereoisomeric Drugs. Industrial and Regulatory Perspectives on Single Isomer Drugs: Regulatory Perspective of the Development of New Stereoisomeric Drugs. Stereochemically Pure Drugs Versus Racemates: An Overview. The Development and Marketing of Single Isomer Drugs vs Racemates: A Legal Perspective.
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Pirkle Type Chiral Stationary Phases;Chiral Selector;chiral;b2AR Agonists;selector;Sudlow Site;racemic;Chiral Stationary Phases;mixture;Chiral Drugs;stationary;Single Enantiomer;phase;SFC.;separation;Plasma Concentration;single;Chiral Separation;enantiomer;Mobile Phase;recognition;Macrocyclic Antibiotic;Individual Enantiomers;SMB Unit;SMB System;Racemic Drug;Stereoselective Binding;Racemic Mixture;Countercurrent Chromatography;Chiral LC;Enantioselective Binding;Chiral Solvating Agent;Ich Guideline;Electromigration Techniques;Single Stereoisomers
Introduction: The Early History of Stereochemistry: From the Discovery of Molecular Asymmetry and the First Resolution of a Racemate by Pasteur to the Asymmetrical Chiral Carbon of Van't Hoff and Le Bel. Stereochemical Terms and Concepts: An Overview. Molecular Chiral Recognition: An Introduction and Overview. The Role of Stereo-Chemistry in the Development of ACE Inhibitors: Nature to Clinic. The Separation, Preparation and Identification of Stereochemically Pure Drugs: Indirect Methods for the Chromatographic Resolution of Drug Enantiomers: Synthesis and Separation of Diastereo-Metric Derivatives. The Direct Resolution of Enantiometric Drugs by Chiral Phase Gas Chromatography. HPLC Chiral Stationary Phases for the Stereochemical Resolution of Enantiometric Compounds: The Current State of the Art. Enantioselective Separations by Capillary Electrophoresis. Recent Advances in the Synthesis of Enantiomerically Pure Compounds. Production Scale Preparation of Enantiomerically Pure Compounds by Chromatography and Synthetic Approaches. Spectrometric Identification and Characterization of Chiral Molecules. Pharmacokinetic and Pharmacodynamic Differences Between Drug Stereoisomers: Stereochemical Considerations in the ADMET Stage of Drug Development. Stereoselective Biotransformations: Toxico-Logical Consequences and Implications. Stereoselective Interactions with Enzymes and Their Use in Drug Development. Stereoselective Transport of Drugs Across Epithelia. Clinical Pharmacokinetics and pharmacodynamics of Stereoisomeric Drugs. Industrial and Regulatory Perspectives on Single Isomer Drugs: Regulatory Perspective of the Development of New Stereoisomeric Drugs. Stereochemically Pure Drugs Versus Racemates: An Overview. The Development and Marketing of Single Isomer Drugs vs Racemates: A Legal Perspective.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
Pirkle Type Chiral Stationary Phases;Chiral Selector;chiral;b2AR Agonists;selector;Sudlow Site;racemic;Chiral Stationary Phases;mixture;Chiral Drugs;stationary;Single Enantiomer;phase;SFC.;separation;Plasma Concentration;single;Chiral Separation;enantiomer;Mobile Phase;recognition;Macrocyclic Antibiotic;Individual Enantiomers;SMB Unit;SMB System;Racemic Drug;Stereoselective Binding;Racemic Mixture;Countercurrent Chromatography;Chiral LC;Enantioselective Binding;Chiral Solvating Agent;Ich Guideline;Electromigration Techniques;Single Stereoisomers
