Understanding PTMs in Neurodegenerative Diseases

Protein extraction and sample preparation methods for shotgun proteomics with central nervous system cells and brain tissue.- Phosphopeptide enrichment techniques: a pivotal step for phosphoproteomic studies.- Post-Translational Modifications during Brain Development.- Aberrant protein glycosylation in brain cancers, with emphasis on glioblastoma.- Post-Translational Modification in Muscular Dystrophies.- Post-translational Modifications in Parkinson's Disease.- Histone Modifications in Neurological Disorders.- Mitochondrial dysregulation and the influence in neurodegenerative diseases.- PTMs: A missing piece for schizophrenia studies.- Post-Translational Modifications in Brain Diseases: A Future for Biomarkers.- Index.

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• Biologia Celular (citologia)
• Neurociências
• Biologia, ciências da vida
• Ciência da Computação
• Biologia molecular

proteomics;neurodegenerative diseases;Phosphopeptides;Glycopeptides;Acetylation;enrichment techniques;false discovery rate (FDR);bioinformatic tools;SLA disease;brain cancer;Phosphoproteome;Glycoproteome;Parkinsons disease;muscular dystrophies;mitochondria dysregulation;schizophrenia;biomarkers