Three Functional States of Proteins

Three Functional States of Proteins

Structured, Intrinsically Disordered, and Phase Separated

Uversky, Vladimir N; Tripathi, Timir

Elsevier Science Publishing Co Inc

12/2024

466

Mole

9780443218095

Pré-lançamento - envio 15 a 20 dias após a sua edição

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1. The three functional states of proteins: Beyond the classical "lock-and-key" paradigm
2. Ordered proteins and structure-function relationship: Classical view
3. Binding of a substrate ("lock and key") and conformational adaption ("induced fit") are different stages of enzyme action
4. Intrinsically disordered proteins: Functionality of chaos
5. Protein Conformation-based Phenotypic Switching and Implications in the Origin and Evolution of Multicellularity
6. Hybrid proteins: Fusion chimeras and natural wonders
7. Functional protein oligomers
8. Fuzzy complexes
9. SMARTQ: Single Molecule Amyloid fibRil Tracking and Quantification. A method for accurately imaging, tracking and quantifying the growth of individual amyloid fibrils using TIRF
10. Structural Polymorphism in Amyloids - States within Proteins' Solid-State
11. Liquid-Liquid Phase Separation, Biomolecular Condensates and Membraneless Organelles: A Novel Blueprint of Intracellular Organization
12. Physical principles and molecular interactions underlying protein phase separation
13. Various levels of phase transitions in the protein universe
14. Targeting phase-separated protein states for drug discovery
15. Protein hydrogels: Structure, Characteristics, and Applications
16. Interactions among the three protein states
17. Protein frustration and fuzziness in the three functional states
18. Thermoresponsive intrinsically disordered protein polymers
19. The evolution and exploration of intrinsically disordered and phase-separated protein states
20. Computational modelling of intrinsically disordered and phase separated protein states
21. Molecular dynamics simulations of intrinsically disordered, fuzzy complexes, and phase separated protein states
22. Biological complexity of the phase separated protein states
23. Protein structure-function continuum
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<p>Protein structure; Intrinsically disordered proteins; Liquid-liquid phase separation; Drug discovery; Protein-protein interaction; Protein function; Membrane-less organelles</p>