Neuroscience of Psychedelics

Foreword by Jose Carlos Bouso, Ph.D.

Preface

1 Brief Introduction to Pharmacology
Etymological Origins
Main Pharmacological Concepts
Nervous System * Neurons, Synapses,
and Action Potentials * Pharmacokinetics and
Pharmacodynamics * Neurotransmitters * Receptors *
Modifying Receptor Function

Why Psychedelic Pharmacology?
Pharmacology and Complexity
References for Further Study

2 Pharmacological Classification of the Main
Psychedelic Drugs: Structures and Major Groups
Simple Tryptamines, including Psilocybin
and DMT
Ergolamines, including LSD
Phenethylamines, including Mescaline and MDMA
NMDA Receptor Antagonists, including Ketamine
New Tryptamines
Atypical Psychedelics
Tabernanthe iboga * Salvia divinorum *
Datura stramonium

References for Further Study

3 Biological Targets of Psychedelic Drugs
Simple Tryptamine Targets
Psilocybin * DMT and Ayahuasca
Ergolamine Targets
LSD * LSA
Phenethylamine Targets
Mescaline * MDMA
Targets of NMDA Receptor Antagonists,
including Ketamine
Targets of New Tryptamines
Targets of Atypical Psychedelics
Ibogaine/Noribogaine * Salvinorin-A *
Datura stramonium

References for Further Study

4 Characteristic Aspects of Psychedelic Pharmacology
PHARMACOKINETICS
Initial Phases of the Processing of Psychedelics
Release * Absorption * Distribution
Metabolism
Metabolism and Aging *
Main Centers and Enzymes Responsible for Metabolism
Relevant Aspects in the Metabolism
of Psychedelic Drugs
Psilocybin * DMT/Ayahuasca * LSD * MDMA * Mescaline *
Ketamine * Ibogaine/Noribogaine * Salvinorin-A *
Tropane Alkaloids
Elimination

PHARMACODYNAMICS
Therapeutic Effects of Psychedelics
Antidepressant, Anti-inflammatory, and Neuroprotective
Effects * Therapeutic Effects of Atypical Psychedelics *
Increased Neuroplasticity * Neurological Evidence of
Psychedelics' Therapeutic Effects * Hormonal Effects *
Psychological Effects
Microdosing Psychedelics as an Emerging Trend
Adverse Effects in the Therapeutic Use of Psychedelics
Toxicity * Studying the Safety of Psychedelics * Health Risks
When Using Psychedelic Drugs Therapeutically
Psychoactive Effects of Psychedelics
Data on Psychedelics' Psychoactive Effects
Tolerance

References for Further Study

5 Harm Reduction in Your Use of Psychedelic Drugs
Take Care of Yourself * Check What You Bought *
Don't Get Creative with Routes of Administration *
Keep Hydrated * Don't Mix * Be Patient

6 A Look into the Future: Promises and Challenges
Marketing of Psychedelic Therapies
The Role of Traditional Knowledge
To Trip or Not to Trip

Appendix I: The Legal Status of Psychedelic Drugs
around the World

Appendix II: Glossary

Index

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• Farmacologia
• Neurologia e neurofisiologia clínica
• Neurociências
• Mente, corpo, espírito: pensamento e prática

NEUROSCIENCE OF PSYCHEDELICS;PHARMACOLOGY AND HUMANITY;GENIS ONA;JOSE CARLOS BOUSO;LSD RESEARCH;DMT STUDIES;PSILOCYBIN THERAPY;AYAHUASCA EFFECTS;MESCALINE;KETAMINE TREATMENTS;IBOGAINE RESEARCH;SALVIA DIVINORUM;MDMA THERAPEUTIC USE;VISIONARY SUBSTANCES;BRAIN AND PSYCHEDELICS;PSYCHEDELIC SCIENCE;HARM REDUCTION;FUTURE OF PSYCHEDELIC THERAPIES;PSYCHEDELIC MEDICINE;SPIRITUALITY AND DRUGS;INDIGENOUS TRADITIONS;PSYCHOACTIVE SUBSTANCES;NEUROLOGICAL EFFECTS;ADDICTION TREATMENT;MEDICAL ANTHROPOLOGY;CULTURAL PSYCHEDELIC USES;ICEERS RESEARCH;UNIVERSITAT ROVIRA I VIRGILI;PSYCHEDELIC PSYCHOTHERAPY;CONSCIOUSNESS EXPANSION;ENTHEOGENIC PRACTICES