Diabetic Foot

Diabetic Foot

Medical and Surgical Management

Schermerhorn, Marc L.; Giurini, John M.; Veves, Aristidis

Springer International Publishing AG

07/2024

592

Dura

9783031557149

Pré-lançamento - envio 15 a 20 dias após a sua edição

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Clinical Features and Diagnosis.-Burden of Diabetic Foot.- Incidence, prevalence of foot ulceration.- Cost of foot ulceration.- The clinical examination of the diabetic foot and the identification of the at risk patient.- Clinical examination.- Screening techniques.- Classification of ulcers (Wagner and Texas classification and others in brief).- (omit vascular examination).- Diabetic neuropathy.- Epidemiology.- Classification.- Clinical features, main emphasis on sensorimotor neuropathy or other neuropathies of lower extremity.- Differential diagnosis.- Treatment.- Clinical features and diagnosis of peripheral arterial disease.- Pathogenesis.- Clinical features.- Diagnostic criteria.- Non-invasive methods, TcPO2, ABI.- Invasive methods.- Proposed algorithm, Reference to the ADA Consensus statement and PAD statement.- Radiographic changes of the diabetic foot.- Plain x-rays.- MRI.- Osteomyelitis diagnosis.- Differential diagnosis of osteomyelitis and Charcot.- MRI spectroscopy.- Principles of care in the diabetic surgical patient.- Control of DM in the surgical patient.- Role of intensive treatment.- Pathophysiology.- Pathophysiology of wound healing in chronic wounds.- Physiology of wound healing.- Pathophysiology of wound healing in DM.- Role of inflammation.- Role of angiogenesis under normal conditions.- Angiogenesis and Diabetes.- Pathophysiology of angiogenesis in the healing of the diabetic foot ulcer.- Factors that Affect Diabetic Wound Healing.- Neuropeptides and wound healing.- Mast cells.- PTP1B in wound healing.- Animal data vs human data: Similarities and differences.- Mechanisms of Vascular Disease in Diabetes.- Micro vs macrocirculation.- PAD in diabetes.- Role of microcirculation.- Omics, their role in understanding the diabetic lower extremity pathophysiology.- Skin Changes in the Diabetic Foot.- Dermatologic conditions Inflammation.- Biomechanics of the diabetic foot.- Foot anatomy related to biomechanics.- Gait Cycle.- Changes in diabetes (LJM, high foot pressures).- Balance in diabetes.- Development of foot ulceration.- Methods to measure foot pressures.- Out of shoe methods.- In shoe methods.- Foot pressure measurements in diabetes.- Cell Therapies: New Frontier for the Management of Diabetic Foot Ulceration.- Limitations of currently available treatments.- Emerging new concepts.- Role of extracellular vesicles, modified mRNA, miRNA and siRNA in diabetic lower extremity complications.- New Biomaterials for the Management of the Diabetic Lower Extremity.- Microbiota of diabetic lower extremity.- Wound infection in diabetes.- Biomarkers of DFU and its healing progress.- Animal models of DFU.- Management of the Diabetic Foot.- Microbiology and Treatment of Diabetic Foot Infection.- Microbiology.- Algorithm of treatment.- Topical vs systemic treatment DFU assessment and wound preparation.- Topical Wound Care Treatment and indications for their use.- Role of dressings.- Selection of dressings, evidence-based evaluation.- Principles for using growth factors.- Review of tested all growth factors so far.- Review of VEGF and PDGF gene therapy clinical trials.- Emphasis on Regranex, the only commercially available growth factor: review of data, indications for using it in clinical practice.- Treatment according to ulcer stages.- Description of different LSE currently in clinical trials or available in clinical practice.- Review of data regarding diabetic foot studies.- Description of other topical, biologically active products.- Surgical Treatment of the Ulcerated Foot.- Lower Extremity Arterial Reconstruction in Patients with Diabetes Mellitus: Principles of Treatment.- Principles of treatment.- Brief description of surgical methods.- Outcomes of surgery.- Indications for angioplasty.- Brief description of angioplasty methods.- Outcomes of angioplasty.- Recommendations by recent guidelines.- We need numerous figures and pictures.- Reconstruction of the diabetic foot.- Reconstruction of diabetic foot.- Reconstruction of soft tissues of the Charcot foot.- Role of dermatomes.- Charcot Arthropathy in the Diabetic Foot.- Epidemiology.- Pathophysiology, stages of disease.- Microcirculation and development of Charcot.- Radiology.- Treatment.- Amputations and rehabilitation.- Major amputations, indications and description of basic principles.- Principles of rehabilitation.- Prostheses.- Organization and Preventive Care.- Organizationof the Diabetic Foot Care team.- Description of the DF care team.- Role of each specialty.- Flow diagram (gate keeper, communication between teams etc).- Quality of Care.- Briefly describe current concepts of quality of care.- Quality of care of DF.- Comparative effectiveness.- Education and behavior modification at the at risk patient.- Psychological profile of the patient with DFU.- Impact of DFU on quality of life.- Techniques to modify behavior.- The role of foot wear in the prevention of diabetic foot problems.- Why we need proper footwear.- Review of studies regarding footwear.- General clinical recommendations.
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diabetic foot ulceration;diabetic lower extremity vascular disease;diabetic neuropathy;impaired diabetic wound healing;lower extremity amputations;Charcot arthropathy