Pharmacology of Potassium Channels

Pharmacology of Potassium Channels

Wang, KeWei; Gamper, Nikita

Springer Nature Switzerland AG

09/2021

545

Dura

Inglês

9783030840518

15 a 20 dias

1087

Descrição não disponível.
Comparison of K+ Channel families.- High-resolution structures of K+ channels.- Pharmacological approaches to studying potassium channels.- Cardiac K+ channels and channelopathies.- Cardiac hERG K+ channel as safety and pharmacological target.- Pharmacology of A-type K+ channels.- Kv7 channels and hyperexcitability disorders.- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain.- Potassium channels in cancer.- Kir channel molecular physiology, pharmacology and therapeutic implications.- The pharmacology of ATP-sensitive K+ channels (KATP).- Calcium-activated K+ channels (KCa) and therapeutic implications.- The Pharmacology of two-pore domain potassium channels.- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits.- Peptide toxins targeting KV channels.- Therapeutic antibodies targeting potassium ion channels.
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Potassium channel;channelopathy;protein structure;pharmacology;electrophysiology;structure-functional relationships;drug discovery;structure-activity relationships (SAR);toxins;antibody