Pathogenesis of Systemic Lupus Erythematosus

Pathogenesis of Systemic Lupus Erythematosus

Insights from Translational Research

Hoi, Alberta

Springer Nature Switzerland AG

11/2021

178

Dura

Inglês

9783030851606

15 a 20 dias

584

Descrição não disponível.
Advances in translational science to identify new therapies for systemic lupus erythematosus.- Hallmark of systemic lupus erythematosus: Role of B Cell Hyperactivity. Fabien B Vincent, William A Figgett and Margaret L Hibbs.- B cell targeted therapies in systemic lupus erythematosus.- Type I Interferons and the perpetuation of a loss of tolerance.- Therapeutic Modulation of the Interferon Pathway in Systemic Lupus Erythematosus.- The concept of co-stimulatory blockade in SLE.- Cytokines: their role in amplifying SLE pathogenesis.- Intracellular targets in SLE.- Regulatory T cells in SLE.- Balancing strategies: GC and GILZ Axis.
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Interferons;JAK/STAT signaling;B-cells depletion;Cytokines;Th17;Immunoproteasomes;small molecule inhibitors;T regulatory cells