PROTAC-Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics

1. Understanding the Ubiquitin Proteasome System - History and Revolution.- 2. PROTACs: Principles and Mechanisms.- 3. Structural Considerations and Chemistry of PROTAC.- 4. Advantages and Disadvantages of PROTACs.- 5. Novel Technologies in PROTAC Design.- 6. Future of trends in the design and development of PROTAC.- 7. Global Regulatory Requirements Applicable for PROTACs.- 8. Tissue-Specific Targeting Strategies with PROTAC Technology.- 9. Clinical Development OF PROTACs.- 10. Toxicological Aspects of PROTACs.- 11. PROTACs in the management of Prostate Cancer.- 12. Exploring the Role of PROTACs for the Treatment of Breast Cancer.- 13. Role of PROTACs in Hematological Malignancies.- 14. Artificial Intelligence and Machine Learning for Exploring PROTAC in Underutilized Cells.- 15. PROTACs in Treatment of Glioma.- 16. Proteolysis Targeting Chimera (PROTACs) an Attractive Technology in CVD Therapeutics: Opportunities and Challenges.- 17. Delivery systems - miniaturised PROTAC, Nano PROTAC, Aptamer-based RNA PROTAC.

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• Oncologia
• Química
• Medicina pré-clínica: ciências básicas
• Farmacologia
• Biotecnologia
• Farmácia / receituário

Proteasome system to target destruction of proteins;PROTAC in clinical applications;Translational insights of PROTAC;Role of PROTAC in tumors;PROTAC design and novel technologies;Delivery systems in PROTAC;PROTAC and toxicological aspects