Mosquito Gene Drives and the Malaria Eradication Agenda

SECTION I THE MALARIA CHALLENGE 1. Current Scenario of Malaria and the Transformative Power of Gene Drive-Based Technologies SECTION II MOSQUITO GENETIC MANIPULATION FOR MALARIA 2. Transgenesis and Paratransgenesis for the Control of Malaria 3. Gene Drives for Anopheles Mosquitoes 4. Gene Drive Applications for Malaria Control SECTION III GENE DRIVE MOSQUITO TRIALS 5. Large Cage Trials of Gene Drive Mosquitoes: Does Size Matter? 6. Field Trial Site Selection for Mosquitoes with Gene Drive: Geographic, Ecological, and Population Genetic Considerations 7. Modeling Priorities as Gene Drive Mosquito Projects Transition from Lab to Field SECTION IV RISK ASSESSMENT AND COMMUNITY ENGAGEMENT 8. Probabilistic Ecological Risk Assessment: An Overview of the Process 9. Community Engagement and Mosquito Gene Drives SECTION V POLICY, REGULATORY, AND ETHICAL CONSIDERATIONS 10. Review of International Regulatory Instruments and Processes 11. Gene Drive Mosquitoes: Ethical and Political Considerations

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• Genética médica
• Epidemiologia e estatística médica
• Genética (não médica)

Probabilistic Ecological Risk Assessment;Gene Drive;Mosquito Populations;Cage Trials;Gene Drive Systems;Gene Drive Technology;Indoor Residual Spraying;Malaria Control;Population Suppression;Malaria Transmission;Anopheles Gambiae;National Academies;Research Gene Drive;Fitness Cost;Vector Control Tools;CI;CRISPR;Vectorial Capacity;Genetic Load;Cartagena Protocol;Probabilistic Risk Assessments;Risk Assessment Endpoints;Suppression Drive;Site Selection;Resistance Alleles