Drug Delivery to the Brain
portes grátis
Drug Delivery to the Brain
Physiological Concepts, Methodologies and Approaches
de Lange, Elizabeth C.M.; Hammarlund-Udenaes, Margareta; Thorne, Robert G.
Springer Nature Switzerland AG
05/2022
806
Dura
Inglês
9783030887728
15 a 20 dias
1400
Descrição não disponível.
Part I-Physiology and Basic Principles of Drug Handling for the CNS.- Anatomy and Physiology of the Blood Brain Barriers.- Drug Delivery to the Brain: Integrating Neuroscience, Physiology, and Brain Barriers Science.- Brain Delivery of Therapeutics via Transcytosis: Types and Mechanisms of Vesicle-Mediated Transport Across the BBB.- Brain- Arachnoid Barrier as an Important Clearance Pathway from CSF.- BBB Pharmacoproteomics: Quantitative Targeted Absolute Proteomics (QTAP): Species Differences.- Drug Metabolism at the BBB and the BCFSB.- PART II-PK Concepts and Methods for Studying CNS Drug Delivery.- Pharmacokinetics Concepts in Brain Drug Delivery.- In Vitro Models of CNS Barriers.- Human In Vitro BBB Models Derived from Pluripotent Stem Cells.- In situ and In vivo Animal Models.- Principles of PET and Its Role in Understanding Drug Delivery to the Brain.- Prediction of CNS PK and PD Using Translational Research Approaches.- Part III-Industrial Approachesfor Investigation of Potential CNS Drugs.- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution.- Prediction of Drug Exposure in the Brain From the Chemical Structure.- Integrated Approach to Optimizing CNS Penetration in Drug Discovery.- Part IV: Strategies for Improved CNS Drug Delivery.- Intranasal Drug Delivery to the Brain.- Blood to Brain Drug Delivery Using Nanocarriers.- Enhancing CNS Exposure Through Brain Endothelial Cell RMT-Exploiting the Transferrin Receptor at the BBB.- Therapeutic Osmotic Modification of the BBB in the Treatment of CNS Pathologies.- Biophysical Perspectives on BBB Permeability Enhancement by Ultrasound and Microbubbles for Targeted Drug Delivery in the Clinical Setting.- Optimization of Blood Brain Barrier Opening With Focused Ultrasound-The Animal Perspective.- CNS Gene Therapy Using Adeno-Associated Virus (AAV) Vectors .- Part V-CNS Drug Delivery in Disease Conditions.- Disease Influence on BBB Transport in Neurodegeneration and Neuroinflammation.- Enhancing Drug Delivery in the Setting of Stroke and Brain Injury.- Drug Delivery to tumor Metastases in the Brain-(Including PK PD Free Fraction Active Conc.).- Drug Delivery to Primary Tumors in the Brain-(Including PK PD Free Fraction Active Conc.).- Appendix:CNS Anatomy, Function, Vasculature and Fluid Exchange: Primer for Drug Delivery Scientists.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
blood-brain barrier;drug delivery blood-brain barrier;transporters;CNS drug delivery;CNS PK and PD;BBB
Part I-Physiology and Basic Principles of Drug Handling for the CNS.- Anatomy and Physiology of the Blood Brain Barriers.- Drug Delivery to the Brain: Integrating Neuroscience, Physiology, and Brain Barriers Science.- Brain Delivery of Therapeutics via Transcytosis: Types and Mechanisms of Vesicle-Mediated Transport Across the BBB.- Brain- Arachnoid Barrier as an Important Clearance Pathway from CSF.- BBB Pharmacoproteomics: Quantitative Targeted Absolute Proteomics (QTAP): Species Differences.- Drug Metabolism at the BBB and the BCFSB.- PART II-PK Concepts and Methods for Studying CNS Drug Delivery.- Pharmacokinetics Concepts in Brain Drug Delivery.- In Vitro Models of CNS Barriers.- Human In Vitro BBB Models Derived from Pluripotent Stem Cells.- In situ and In vivo Animal Models.- Principles of PET and Its Role in Understanding Drug Delivery to the Brain.- Prediction of CNS PK and PD Using Translational Research Approaches.- Part III-Industrial Approachesfor Investigation of Potential CNS Drugs.- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution.- Prediction of Drug Exposure in the Brain From the Chemical Structure.- Integrated Approach to Optimizing CNS Penetration in Drug Discovery.- Part IV: Strategies for Improved CNS Drug Delivery.- Intranasal Drug Delivery to the Brain.- Blood to Brain Drug Delivery Using Nanocarriers.- Enhancing CNS Exposure Through Brain Endothelial Cell RMT-Exploiting the Transferrin Receptor at the BBB.- Therapeutic Osmotic Modification of the BBB in the Treatment of CNS Pathologies.- Biophysical Perspectives on BBB Permeability Enhancement by Ultrasound and Microbubbles for Targeted Drug Delivery in the Clinical Setting.- Optimization of Blood Brain Barrier Opening With Focused Ultrasound-The Animal Perspective.- CNS Gene Therapy Using Adeno-Associated Virus (AAV) Vectors .- Part V-CNS Drug Delivery in Disease Conditions.- Disease Influence on BBB Transport in Neurodegeneration and Neuroinflammation.- Enhancing Drug Delivery in the Setting of Stroke and Brain Injury.- Drug Delivery to tumor Metastases in the Brain-(Including PK PD Free Fraction Active Conc.).- Drug Delivery to Primary Tumors in the Brain-(Including PK PD Free Fraction Active Conc.).- Appendix:CNS Anatomy, Function, Vasculature and Fluid Exchange: Primer for Drug Delivery Scientists.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
