Design and Analysis of Cross-Over Trials
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Design and Analysis of Cross-Over Trials
Jones, Byron; Kenward, Michael G.
Taylor & Francis Ltd
10/2024
438
Mole
9781032919898
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Introduction. The 2x2 Cross-Over Trial. Higher-Order Designs for Two Treatments. Designing Cross-Over Trials. Analysis of Continuous Data. Analysis of Discrete Data. Bioequivalence Trials. Case Study: Phase I Dose-Response Noninferiority Trial. Case Study: Choosing a Dose-Response Model. Case Study: Conditional Power. Case Study: Proof of Concept Trial with Sample Size Re-Estimation. Case Study: Blinded Sample Size Re-Estimation in a Bioequivalence Study. Case Study: Unblinded Sample Size Re-Estimation in a Bioequivalence Study That Has a Group Sequential Design. Case Study: Various Methods for an Unblinded Sample Size Re-Estimation in a Bioequivalence Study. Appendix A: Least Squares Estimation. Bibliography.
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WASO Time;Average Total Sample Size;THE 2 x 2 CROSS-OVER TRIAL;Sample Size Re-estimation;HIGHER-ORDER DESIGNS FOR TWO TREATMENTS;OLS Estimator;DESIGNING CROSS-OVER TRIALS FOR THREE OR MORE TREATMENTS;Interim Analysis;ANALYSIS OF CONTINUOUS DATA;Fixed Subject Effects;BIOEQUIVALENCE TRIALS;Data Set;Noninferiority;Toss Procedure;Dose Response;Random Subject Effects;Conditional Power;Effect DF DF;Direct Treatment Effect;Bioequivalence;Yi Jk;Baseline Measurement;Bioequivalence Study;Continuous Data Analysis;Proc Glimmix;Discrete Data Analysis;Estimate SE;Two-Treatment Design;Single Interim Analysis;Higher-Order Design;Linear Mixed Models;2x2 Crossover Trial;Unblinded Interim Analysis;Crossover Trial Analysis;Sequence Groups;Crossover Trial Design;Balaam's Design;Crossover Trial;AUC Cmax;2x2 Cross-Over Trial;Group Sequential Design;Cross-Over Trial Analysis;Proc Freq;Cross-Over Trial Design;Orthogonal Latin Squares;Cross-Over Trial;Recalculated Sample Size
Introduction. The 2x2 Cross-Over Trial. Higher-Order Designs for Two Treatments. Designing Cross-Over Trials. Analysis of Continuous Data. Analysis of Discrete Data. Bioequivalence Trials. Case Study: Phase I Dose-Response Noninferiority Trial. Case Study: Choosing a Dose-Response Model. Case Study: Conditional Power. Case Study: Proof of Concept Trial with Sample Size Re-Estimation. Case Study: Blinded Sample Size Re-Estimation in a Bioequivalence Study. Case Study: Unblinded Sample Size Re-Estimation in a Bioequivalence Study That Has a Group Sequential Design. Case Study: Various Methods for an Unblinded Sample Size Re-Estimation in a Bioequivalence Study. Appendix A: Least Squares Estimation. Bibliography.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
WASO Time;Average Total Sample Size;THE 2 x 2 CROSS-OVER TRIAL;Sample Size Re-estimation;HIGHER-ORDER DESIGNS FOR TWO TREATMENTS;OLS Estimator;DESIGNING CROSS-OVER TRIALS FOR THREE OR MORE TREATMENTS;Interim Analysis;ANALYSIS OF CONTINUOUS DATA;Fixed Subject Effects;BIOEQUIVALENCE TRIALS;Data Set;Noninferiority;Toss Procedure;Dose Response;Random Subject Effects;Conditional Power;Effect DF DF;Direct Treatment Effect;Bioequivalence;Yi Jk;Baseline Measurement;Bioequivalence Study;Continuous Data Analysis;Proc Glimmix;Discrete Data Analysis;Estimate SE;Two-Treatment Design;Single Interim Analysis;Higher-Order Design;Linear Mixed Models;2x2 Crossover Trial;Unblinded Interim Analysis;Crossover Trial Analysis;Sequence Groups;Crossover Trial Design;Balaam's Design;Crossover Trial;AUC Cmax;2x2 Cross-Over Trial;Group Sequential Design;Cross-Over Trial Analysis;Proc Freq;Cross-Over Trial Design;Orthogonal Latin Squares;Cross-Over Trial;Recalculated Sample Size
