Chemistry of Protein and Nucleic Acid Cross-Linking and Conjugation

Chemistry of Protein and Nucleic Acid Cross-Linking and Conjugation

Jameson, David M.; Wong, Shan S.

Taylor & Francis Ltd

10/2024

622

Mole

9781032918174

Pré-lançamento - envio 15 a 20 dias após a sua edição

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Overview of Protein Conjugation. Review of Protein and Nucleic Acid Chemistry. Reagents Targeted to Specific Functional Groups. How to Design and Choose Cross-Linking Reagents. Homobifunctional Cross-Linking Reagents. Heterobifunctional Cross-Linkers. Multifunctional Cross-Linking Reagents. Monofunctional and Zero -Length Cross -Linking Reagents. General Approaches for Chemical Cross-Linking. Analysis of Cross-Linked Products. Applications of Chemical Cross-Linking to the Study of Biological Macromolecules. Applications of Chemical Conjugation in the Preparation of Immunoconjugates and Immunogens. Application of Chemical Conjugation for the Preparation of Immunotoxins and Other Drug Conjugates for Targeting Therapeutics. Application of Chemical Conjugation to Solid-State Chemistry. Amino Group-Directed Homobifunctional Cross-Linkers. Sulfhydryl Group- Directed Homobifunctional Cross-Linkers. Phenolate- and Imidazolyl-Group-Directed Reagents: Bisdiazonium Precursors. Group Selective Heterobifunctional Cross-Linkers. Photoactivatable Heterobifunctional Cross-Linking Reagents.
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Cross-linking Reagents;Cross-linked Product;Reagents Targeted to Specific Functional Groups;Nucleic Acid;Homobifunctional Cross-Linking Reagents;Amino Groups;Multifunctional Cross-Linking Reagents;Heterobifunctional Reagents;Analysis of Cross-Linked Products;Cross-link DNA;Application of Chemical Conjugation to Solid-State Chemistry;Homobifunctional Reagents;DNA Interstrand Cross-link;Nucleic Acid Cross-Linking;DNA Interstrand;Amino Acid Side Chains;Interstrand Cross-links;Heterobifunctional Cross-linkers;Nitrogen Mustards;DNA Crosslinking;PBD Dimer;Reporter Groups;DNA Duplex;Protein Protein Interactions;Dimethyl Suberimidate;Sulfhydryl Group;Cross-linking Reaction;Sec Experiment;DNA Minor Groove;DNA Alkylation