Cell and Gene Therapies for Neurologic Diseases

Cell and Gene Therapies for Neurologic Diseases

Barker, Roger A.; Federoff, Howard J.

Elsevier - Health Sciences Division

10/2024

480

Dura

Inglês

9780323901208

Pré-lançamento - envio 15 a 20 dias após a sua edição

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Section 1. Cellular Therapies
1. Introduction to stem cell biology and its role in treating neurologic disorders
2. History of cellular grafting for CNS repair - A clinical perspective
3. Autologous vs. heterologous cell replacement strategies for Parkinson disease and other neurologic diseases

Section 2. Gene therapies
4. Viral vectors and gene delivery to the central nervous system
5. Viral versus Non-viral approaches

Section 3. General Considerations (for cell and gene therapies)
6. Clinical/surgical considerations
7. Ethics of gene and cell therapy development for neurological disorders
8. Clinical trial designs and endpoints
9. Immunology of such therapies
10. Scaling of cell and gene therapies to population
11. The Health economics of cell and gene therapies

Section 4. Disease specific interventions using cells and genes
12. Disease specific interventions: The use of cell and gene therapies for Parkinson disease
13. Using gene or cell therapies to treat Huntington's disease
14. Disorders of the motorneuron including ALS and SMA
15. Gene and cell-based therapies for retinal and optic nerve disease
16. Disease specific interventions using cell therapies for spinal cord disease/injury
17. Stem and progenitor cell-based therapy of myelin disorders
18. Cell and gene therapy in neuro-oncology
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gene therapy; cell therapy; cellular therapeutics; neurological diseases; Huntington's; Parkinson's; ALS; Stroke; Epilepsy; Demyelination