Biology of Bladder Cancer

Part I. Fundamentals of Bladder Cancer.- Chapter 1. Epidemiology of Bladder Cancer.- Chapter 2. Genetic Predisposition to Bladder Cancer.- Chapter 3. Human Urothelium.- Chapter 4. Bladder Cancer Pathology.- Chapter 5. Overview of Standard Therapy of Non Muscle-Invasive Bladder Cancer.- Chapter 6. Overview of Standard Therapy of Muscle-Invasive Bladder Cancer.- Part II. Molecular Genetics and Oncogenesis in Bladder Cancer.- Chapter 7. From Normalcy to Neoplasia: Mutational Events during Bladder Tumor Evolution.- Chapter 8. Cell Cycle Regulators as Oncogenic Drivers in Bladder Cancer.- Chapter 9. DNA Repair Pathway Alterations in Bladder Cancer.- Chapter 10. DNA Methylation and Chromatin Regulators in Bladder Cancer.- Part III. Pathogenesis and Microenvironment Dynamics in Bladder Cancer.- Chapter 11. Molecular Pathogenesis: Field Cancerization and Clonal Evolution in Urothelial Cancer Initiation and Progression.- Chapter 12. The Bladder Tumor Microenvironment.- Part IV. Molecular and Histological Subtypes of Bladder Cancer.- Chapter 13. Molecular Subtypes of Non-Muscle-Invasive Bladder Cancer.- Chapter 14. Molecular Subtypes of Muscle-Invasive Bladder Cancer.- Chapter 15. Molecular Features of Divergent Differentiation and Histological Subtypes in Bladder Cancer.- Part V. Experimental Models of Bladder Cancer.- Chapter 16. The Emerging Landscape of Mouse Bladder Cancer Models.- Chapter 17. In Vitro Bladder Cancer Models.- Part VI. Biomarkers for Diagnosis and Treatment of Bladder Cancer.- Chapter 18. Urine Biomarkers for Bladder Cancer Diagnosis and Screening.- Chapter 19. Blood-Based Biomarkers for Bladder Cancer Diagnosis and Prognosis.- Chapter 20. Mechanisms and Biomarkers of Response to BCG and Chemotherapy in Bladder Cancer.- Part VII. Therapeutic Application based on Molecular Insights.- Chapter 21. New Treatment Approaches in Non-Muscle-Invasive Bladder Cancer.- Chapter 22. New Treatment Approaches in Muscle-Invasive Bladder Cancer.- Chapter 23. Targeting the Immune Checkpoint in Bladder Cancer.- Part VIII. Future Directions in Bladder Cancer Research.- Chapter 24. Future Directions in Bladder Cancer Research and Clinical Implications.

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• Oncologia

Cell Cycle Regulation;DNA Methylation;DNA Repair Genes;Immune Checkpoint;Metastasis;MIBC;Muscle Invasive Bladder Cancer;NMIBC;Non-Muscle Invasive Bladder Cancer;Oncogenic Drivers;PDX Models;Tumor Microenvironment;Urothelium;Urine Biomarker;Urothelial Cancer